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acuC [2018-07-17 19:25:30]
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acuC [2018-07-17 19:25:30]

protein deacetylase for the control of AcsA activity
locus
BSU29710
pI
5.06
mw
42.83 kDa
protein length
387 aa Sequence Blast
gene length
1161 bp Sequence Blast
function
control of AcsA activity
product
AcsA deacetylase
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 2|Metabolism] → [category|SW 2.2|Carbon metabolism] → [category|SW 2.2.2|Utilization of specific carbon sources] → [category|SW 2.2.2.1|Utilization of organic acids]
  • [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.1|Utilization of lipids] → [category|SW 2.4.1.3|Utilization of fatty acids]
  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.4|Protein modification] → [category|SW 3.3.4.5|Protein acetylases/ deacetylases]

    • Gene

    Coordinates
    3,041,392 → 3,042,555

    The protein

    Catalyzed reaction/ biological activity

  • deacetylates (and thereby activates) [protein|6671E7D85E99D349679F0E9D825DC035D10FFD2E|AcsA] (together with [protein|A0A6CB19191A251BB5600C18E039978A9A34933C|SrtN]) [Pubmed|19136592]

    • Protein family

  • histone deacetylase family (according to Swiss-Prot) class I histone deacetylase

    • Expression and Regulation

    Operons

    genes
    [gene|17C3F56CE859BCD7A282C144C46CC92D3506ABF6|acuA]-[gene|FC9981CFB9D7EB8ACDA3032EC2F0538988F277AA|acuB]-[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]
    description
    [Pubmed|7934817]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|7913927], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]

    • regulatory mechanism

  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|7913927], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • repressed by glucose (3.4-fold) ([protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]) [Pubmed|7913927,12850135]

    • additional information

  • the mRNA is quite stable (half-life 5 min) [http://www.ncbi.nlm.nih.gov/sites/entrez/12884008 PubMed]
    • view in new tab

    Biological materials

    Mutant

  • GP1209 (''[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]''::''kan''), available in [SW|Stülke] lab
  • GP1213 (''[gene|A0A6CB19191A251BB5600C18E039978A9A34933C|srtN]''::''cat'')(''[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]''::''kan''), available in [SW|Stülke] lab
  • 1A887 ( ''acuC''::''spc''), [Pubmed|16855235], available at [http://pasture.asc.ohio-state.edu/BGSC/getdetail.cfm?bgscid=1A887&Search=1A887 BGSC]
  • BKE29710 (Δ[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE29710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCTCATAGCAGATCCCTTTG, downstream forward: _UP4_CAAAGAACAAAGTAAAAAAC
  • BKK29710 (Δ[gene|1255813797A83D835E0656A2AAAD361B5BB2094B|acuC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK29710 BGSC], [Pubmed|28189581], upstream reverse: _UP1_TCTCATAGCAGATCCCTTTG, downstream forward: _UP4_CAAAGAACAAAGTAAAAAAC

    • References

  • 7913927,16855235,7934817,19136592,18487328,26098117